Chronic Spontaneous Urticaria (Hives)


18 and Over

Study Topic


What is Chronic Spontaneous Urticaria?

Chronic Spontaneous Urticaria, or hives, is a debilitating disease characterized by itchy red or skin-colored welts lasting for more than 6 weeks. About 20% of all people get hives. They’re often caused by an allergic reaction to a food or drug. Usually, they go away quickly. For a small number of people though, hives come back again and again, with no known cause. Urticaria is defined as chronic when the symptoms spontaneously present and reoccur daily or almost daily for at least six weeks. It is described as spontaneous when symptoms are not triggered by any identified external factor.

Common Causes of Chronic Spontaneous Urticaria

Even though doctors can’t say for sure what causes hives, they do know things that can lead to flare-ups. They include:

  • Alcoholic drinks
  • Tight clothing
  • Non-steroidal anti-inflammatory drugs (NSAIDS) like aspirin and ibuprofen
  • Exercise
  • Cold
  • Heat

How to Recognize Chronic Spontaneous Urticaria

Chronic Spontaneous Urticaria is inadequately controlled by H1-antihistamines. Women are twice as likely as men to be diagnosed with the disease and most people first develop symptoms between the ages of 20 and 40.

How to Enroll

Hives don’t last forever. Most people have them for 1 to 5 years but for a small number of people, it can last longer. There’s no known cure, but medicines and lifestyle changes can help you feel better. If your quality of life is currently adversely affected by hives and you are over the age of 18, you may qualify for a new research study or clinical trial that measures the effectiveness of a new oral medication used to treat chronic hives.

Ready to Volunteer?

Volunteer today to see if you qualify for our Hives clinical research study, Qualified volunteers may be compensated for time and travel.