C. Diff


50 and Older

Study Topic


Clostridioides difficile (also known as C. diff) is a bacterium that can cause gastrointestinal symptoms ranging from diarrhea to life-threatening inflammation of the colon. Illnesses caused by C. diff are most common in older individuals being treated in hospitals or long-term care facilities. It’s estimated to cause almost half a million illnesses in the United States each year and about 1 in 5 patients who get C. diff will get it again.

Common Causes of C. diff

The symptoms of C. diff are fever, diarrhea, and abdominal pain. Serious complications of C. difficile colitis include dehydration, rupture of the colon, and spread of infection to the abdominal cavity or body. Severe infection is life-threatening.

How to Recognize C. diff

The most common cause of C. diff is treatment with antibiotics. Antibiotics are believed to suppress normal colonic bacteria that usually keep C. diff from multiplying and causing colitis. Most cases of C. diff occur in patients in the hospital, but the number of cases that occur among individuals not having been in or recently discharged from the hospital has greatly increased.

How to Enroll

If you are 50 years of age or older, have taken antibiotics recently or have been hospitalized recently, but have not been diagnosed with primary C difficile infection (CDI), you may be eligible for a new study or clinical trial to evaluate a new C. diff vaccine.

Ready to Volunteer?

Volunteer today to see if you qualify for our C. Diff clinical research study, Qualified volunteers may be compensated for time and travel.